Over the last decade, our appreciation of the importance of the nucleolus for cellular function has progressed from the ordinary to the extraordinary. We no longer think of the nucleolus as simply the site of ribosome production, or a dynamic subnuclear body noted by pathologists for its changes in size and shape with malignancy. Instead, the nucleolus has emerged as a key controller of many cellular processes that are fundamental to normal cell homeostasis and the target for dysregulation in many (...) human diseases; in some cases, independent of its functions in ribosome biogenesis. These extra‐nucleolar or new functions, which we term “non‐canonical” to distinguish them from the more traditional role of the nucleolus in ribosome synthesis, are the focus of this review. In particular, we explore how these non‐canonical functions may provide novel insights into human disease and in some cases new targets for therapeutic development. (shrink)

Should Lesbian and women's events have policies banning sadomasochists or sadomasochistic acts? This question is being heatedly debated in the Lesbian community. In this paper, I examine the moral and political problems with sadomasochism from a Lesbian-feminist perspective, concluding that sadomasochism is antifeminist and antiliberatory for many reasons. Then, given this conclusion, I explore how events such as women's music festivals should determine their policies about sadomasochism.

Fazer a genealogia do poder nunca foi o propósito claro de Foucault. No entanto, a questão do poder foi tema recorrente em suas investigações a ponto de estudiosos do trabalho do filósofo sugerirem uma divisão e organização de seu trabalho a partir de três eixos teóricos. Dentro dessa perspectiva, a analítica do poder marcaria a trajetória filosófica de Foucault na década de 1970. De fato, até 1994, ano de publicação do conjunto de textos, entrevistas e conferências de Foucault no Dits (...) et écrits, a questão da analítica do poder era majoritariamente conhecida a partir de livros como Surveiller et punir e Histoire de la sexualité I: la volonté de savoir. Com o início da publicação dos cursos no Collège de France a partir de 1997 as interpretações a respeito da analítica do poder sofrem um alargamento. Mas é somente em 2015 que a totalidade dos cursos de Foucault no Collège de France foram publicados, abrindo um importante caminho para a investigação a respeito das primeiras reflexões a respeito do poder. No presente artigo procuramos mostrar como os primeiros passos da analítica do poder de Michel Foucault se dá a partir de um contexto gauchiste ainda configurado em termos de dinástica do saber. Nesse sentido, procuramos mostrar como o período da dinástica corresponde a um esboço teórico, tentativas primeiras de conceituação do poder, marcadamente desenvolvido em contraposição com o marxismo. Essa contraposição se dá sobretudo na recusa tanto do esquema marxista de infra-superestrutura, quanto do modelo contratualista de sociedade estatal. (shrink)

El populismo sigue siendo un fenómeno controversial, a pesar de los aportes de Ernesto Laclau o Chantal Mouffe, guiados a comprenderlo. De ahí que, en este trabajo, que rechaza los reduccionismos y los esencialismos con los cuales se ha juzgado a las diversas manifestaciones de proyectos políticos populistas; se intenta desentrañar los alcances del populismo, yendo más allá de la concepción actual que bien lo entiende como mera reacción contestaria o antípoda de las instituciones. Profundizando en la capacidad que tiene (...) para construir sentido y no solo como estrategia para la conquista del poder político. (shrink)

This article proposes a study on love as an ambivalent experience that incorporates, along with the pleasant, essentially pain, and whose experience requires preparation and self-knowledge. To do this, I have taken as a starting point fragment 130 of sappho and the Platonic notion of soul of Phaedrus, to culminating in a reconsideration of pain as a necessary experience that allows the understanding of what sappho’s calls “bittersweet” love. The erotic suffering is considered in two ways: from the deep pain (...) that leads to the abyss, to the pain that is in balance with “the sweetness” of love. (shrink)

Resumen: En el presente artículo se realiza una comparación crítica de dos enfoques sobre los fundamentos de la teoría microeconómica del comportamiento del consumidor, a saber: el enfoque utilitarista y el de la preferencia revelada. Se lleva a cabo un análisis de la preferencia revelada en el contexto de la introducción de restricciones a la función de elección en la teoría de la decisión. Se evalúan sus ventajas y limitaciones en contraste con el problema de la utilidad propio del punto (...) de vista subjetivista de la teoría utilitarista. Y se confronta la capacidad explicativa de los distintos modelos de agencia racional sobre las bases de las curvas de demanda. Asimismo, se desarrolla una crítica formal al método de la preferencia revelada en entornos estratégicos de decisión.: This article makes a critical comparison of two approaches to the foundations of the microeconomic theory of consumer behavior, namely: the utilitarian approach and that of the revealed preference theory. An analysis of revealed preference is carried out in the context of introducing restrictions to the choice function in decision theory. Its advantages and limitations are evaluated in contrast to the utility problem proper to the subjectivist point of view of utilitarian theory. And the explanatory capacity of the different models of rational agency is confronted on the bases of the demand curves. Furthermore, a formal critique of the revealed preference method is developed in strategic decision-making environments. (shrink)

The question around foreigners and their obligation to respect and fulfil the national - or civil - norms of the territory where they are; has become due the migration and multicultural movements once again a key one. Addressed by a multitude of authors along the centuries, the question has been answered based on the different placements around juridical and political concepts like citizenship, sovereignty, authority or law. In this investigation, the doctrinal development carried out around the obligatory nature of the (...) civil norm for foreigners in Spanish scholasticism is going to be considered. Specifically, due to its thoroughness and depth, the doctrine done by Francisco Suarez is going to be critically analysed. Once the answer given in our author's doctrine to the question posed has been established, we will consider the possible influences in the Anglo-Saxon sphere. (shrink)

This paper argues that, despite a few positive developments in recent decades, the global labour landscape is still notoriously marked by forms of precarity, unlivability and exploitation. Thus, while acknowledging that contemporary experiences of work are complex and diverse, it emphasises the detrimental impact that the neoliberal production of precarity and the phenomenon of social acceleration are having on them all. In this sense, it contends that temporal pressure and the control of workers’ time is a nodal point from which (...) various forms of labour precarity derive. With a theoretical framework based on the works of Rancière, Butler and Rosa among others, this paper seeks to illuminate the relationship between the accelerated temporalities of neoliberal capitalism and emerging forms of labour precarity. It does so, first, by characterising contemporary time regimes and identifying the productivist rationality that underpins them. It then analyses the manner in which productivism effectively materialises in workplace surveillance, automation and logistical technologies. Finally, it presents two compelling examples that illustrate how neoliberal capitalist time regimes, their productivist normative code, and their association with the latest technology not only perpetuate disciplinary mechanisms of old, but also enable new overlappings between various forms of labour precarity and socially assigned disposability. (shrink)

The symbol refers to “substituted entities,” to something other than what is translated by the direct meaning of the expression. One principle of symbolization is that of placing ourselves in the order of recognition which opens an access path to knowledge, that of keeping us within the horizon of remembrance in order to recompose the initial truth in its fullness and communicate its strong impression. In parallel with the universe ordered, according to objective laws, a symbolic universe is developed, ordered (...) according to its own laws (universes between the structures of which analogies are possible). Starting from these premises, in my paper I will refer in particular to the anthropological and cultural relevance of religious discourse and artistic language, to the interferences between them. (shrink)

In this paper I intend to show that the differences between the aesthetic experience and the religious experience do not “close” the dialogue between the aesthetic man and the religious man. Although these two types of experience are distinguished by “the way in which everyone understands its object” —there is a similarity between aesthetic experience and religious experience which resides in the fact that “towards their object, both are in an attitude of contemplation”.

This book brings together a series of insightful chapters about the emerging topic of character education in the university. As the editors of this volume state, most recent initiatives aimed to cu...

Exposición realizada por la Doctora en Filosofía Contemporánea Lorena Souyris Oportot, en el ciclo de conversaciones “Crítica a la Epidemiología Política. Prácticas y racionalidad neoliberales en tiempos de pandemia”, organizado por el equipo editorial de la Revista de Filosofía Otrosiglo, octubre – diciembre 2020. Disponible en Youtube, canal Revista Otrosiglo. Lecture by Lorena Souyris Oportot, Ph. D., in the cycle of conversations “Criticism to the Political Epidemiology. Neoliberal practices and rationality in times of pandemics”, event organized by the (...) editorial team of the Philosophy Magazine Otrosiglo, october – december 2020. Available on Youtbe, channel Revista Otrosiglo. (shrink)

A partir de un estudio teórico, el presente artículo busca examinar las dinámicas estético-afectivas que se manifiestan en campos de experiencias y de (con)tactos los cuales han ordenado prácticas in-mundas. Tal examen, asume una reflexión que apunta a problematizar la insensibilidad, no sólo en cuanto antinomia de la sensibilidad, sino igualmente, como una analítica de lo insensible que ha regulado un sentimiento de indiferencia frente al otro organizando una forma de habitar el mundo actual que se cumpliría en la particularidad (...) individualizada y en la contingencia, revelando así una disponibilidad para lo insensible. La tesis que se intenta sostener es que esta disponibilidad se originaría desde una tópica psíquica la cual legitimaría la idea lacaniana de que el sujeto surge como efecto de una diferencia significante, a saber, de una grieta constitutiva la cual conlleva una relación excéntrica con el Yo y que se manifestaría en una segregación interna exteriorizada en la antinomia sensibilidad/insensibilidad; pero también, reflejada en otra antinomia hospitalidad/inhospitalidad en la constitución de la experiencia de cómo hacemos mundo. (shrink)

With the arrival of the nineteenth century, a process of change guided the treatment of three basic elements in the development of mathematics: rigour, the arithmetization and the clarification of the concept of function, categorised as the most important tool in the development of the mathematical analysis. In this paper we will show how several prominent mathematicians contributed greatly to the development of these basic elements that allowed the solid underpinning of mathematics and the consideration of mathematics as an axiomatic (...) way of thinking in which anyone can deduce valid conclusions from certain types of premises. This nineteenth century stage shares, possibly with the Heroic Age of Ancient Greece, the most revolutionary period in all history of mathematics. (shrink)

Desde mediados del siglo XX, el devenir de la salvaguarda relacionada con las viviendas ha avanzado desde la monumentalidad hasta el contexto, desde la individualización hasta la caracterización paisajística, desde las condiciones materiales hasta los aspectos vivenciales. Sin embargo, amparar el cuerpo de las residencias típicas de cada territorio, en especial en los dinámicos marcos urbanos, resultó —y resulta— un desafío. Las experimentaciones de propuestas hacia un amparo residencial a más largo plazo han coincidido en dos aspectos de interés: la (...) promoción de indicadores de sustentabilidad patrimonial, inscriptos en cada marco estatal-local preservacionista, junto con el reconocimiento y el tratamiento del rol usuario. En este sentido, desde variables histórico-arquitectónicas y sociales se propuso la construcción y la aplicación de indicadores de sustentabilidad patrimonial residencial para visibilizar problemas y potencialidades hacia una formulación de estrategias de preservación apropiadas. Para ello se abordó la ciudad de Mar del Plata, una aglomeración intermedia bonaerense paradigmática debido a sus dinamismos pasados y presentes, con foco en sus chalets “estilo Mar del Plata” y sus usuarios. Se analizaron dos barrios históricos —Stella Maris y La Perla—, donde sobrevive una relevante diversidad de chalets en un marco de múltiples riesgos que afectan su permanencia. Desde una perspectiva principalmente cualitativa, apoyada por datos cuantitativos, se articularon relevamientos in situ, fuentes escritas (investigaciones previas, artículos científicos, cartas patrimoniales), gráficas (planimetrías, fotografías, imágenes aéreas) y orales (encuestas, entrevistas). De esta manera, la indagación desarrollada permitió avanzar en renovados caminos para progresar en la salvaguarda del legado residencial contextual. (shrink)

Este artículo analiza lo que nos cuentan las imágenes fotográficas en su reverso y en las huellas del verso, a través de las anotaciones, marcas o descripciones que contienen, que entregan información importante de su contexto de producción, de los sujetos u objetos fotografiados y de su trayectoria. Así, se configura un sentido apropiado de la imagen. Este artículo, pone el foco en imágenes fotográficas escolares porque representan un espacio de convivencia particular y de intercambio de experiencias que, en alguna (...) medida, se captura y resguarda en ellas. En los pliegues, en los bordes oscurecidos o desgastados, en los márgenes marchitos y en las marcas de óxido o de otros materiales, es posible también encontrar historias, restos de memorias, afectos y rostros en un contrapunto que va más allá de la motivación del fotógrafo para captar el instante en un encuadre específico. Para el análisis, se presentan algunas imágenes fotográficas pertenecientes al archivo escolar de un centro educativo de la ciudad de Talca en la región del Maule (Chile), pues permiten develar el significado familiar, mnemónico y comunitario que estas adquieren al reunirse en ese repertorio. Este valor igualmente se desprende de la observación del material oculto en el reverso y de las marcas del verso de las imágenes fotográficas. (shrink)

Type 2 diabetes has been considered a public health threat due to its growing prevalence, particularly in the older population. It is important to know the effects of psychosocial stress and its potential consequences for some basic cognitive processes that are important in daily life. Currently, there is very little information about how people with T2D face acute psychosocial stressors, and even less about how their response affects working memory, which is essential for their functionality and independence. Our aim was (...) to characterize the response to an acute laboratory psychosocial stressor and its effects on WM in older people with T2D. Fifty participants with T2D from 52 to 77 years old were randomly assigned to a stress or control condition. Mood and physiological responses to tasks were measured. In addition, participants completed a WM test before and after the stress or control task. Our results showed that the TSST elicited higher negative affect and greater C and sAA responses than the control task. No significant differences in WM were observed depending on the exposure to stress or the control task. Finally, participants who showed higher C and sAA responses to the stressor had lower WM performance. Our results indicate that medically treated older adults with T2D show clear, typical mood and physiological responses to an acute psychosocial stressor. Finally, the lack of acute psychosocial stress effects on WM suggests that it could be related to aging and not to this disease, at least when T2D is adequately treated. (shrink)

El contexto cordobés en torno a 1969 fue especialmente fértil para la emergencia de prácticas artísticas militantes. En el marco de la Universidad Nacional de Córdoba movilizada por los acontecimientos sociales y políticos, surgió Libre Teatro Libre (LTL), que fue luego uno de los grupos de teatro militante más reconocidos de la época. Realizaré un recorrido crítico por el proceso político en torno al Cordobazo a través del análisis de la experiencia de LTL, poniendo de relieve aspectos significativos que operan (...) como metonimia (por asociación o por contraste) de otras experiencias, para reflexionar en torno a problemáticas como las conexiones entre militancia y experimentación; las apuestas estéticas en función de los objetivos artístico-políticos; entre otras. (shrink)

In this study I intend to prove that there is a close connection between ethical purposes of Environmental Philosophy as World Philosophy and the idea of sacred nature as part of the “world” in a phenomenological sense, which includes sacred space as defined in the philosophy of religion. The main points that intersect here are: the idea of sacred space; the perception of virtue in a sacred world; the beauty of creation: nature, life, human sensibility. The theoretical background of this (...) study contains points of view that express phenomenological, hermeneutic, theological, and aesthetic conceptions belonging to authors and exegetes such as Mircea Eliade, William E. Paden, David Cave, Ion Ianoși, Douglas Allen, Arnold Berleant, and Vincent Blok. I believe that the neglect of the environment-as-a-condition-of-life (the consequences of which can already be seen in ecological imbalances) is caused by, among other factors, the desacralization of human attitudes towards nature and the world of life. Few people still have a feeling of sacred nature or the aesthetic emotion of perceiving beauty in natural forms. The relationship with the environment and nature is reduced to its exploitation as a source of economic profit or as a way for spending free time, a source of personal comfort devoid of any spiritual significance. Surely we cannot go back to archaic religions or medieval Christianity, but we can reintegrate into our moral values something of those cultures’ admiration and respect for the beauty/sublimity of nature and the world as expressions of divine creation, as something sacred. Philosophical debates related to this retrieval and their dissemination could be part of solving the ecological problems of the contemporary world. (shrink)

ABSTRACT The work of Giorgio Agamben is punctuated by constant references to Michel Foucault’s work, so that the latter appears as an important theoretical framework for the former. However, an effort to bring the two authors together proves to be quite problematic as it is perceived that the Italian philosopher operates certain methodological and conceptual categories fundamental to Foucauldian thought in a radically different way from the French philosopher. Such incompatibility is presented with greater clarity when we propose to explore (...) the theme of the destituent in Agamben’s work, from which ontology, politics and ethics intersect, revealing the differences between the two philosophers. Thus, in order to expose the limits of this approximation, it will first be explored the methodological distinctions between the two authors in their approach of the problem of ‘power’, as well as the way in which the concept is formulated in the work of each of them. Next, the general lines of the agambenian ‘modal ontology’ and the ‘ethics of inoperability’ will be presented in order to conclusively explain the divergence between the ethical solutions proposed by Foucault and Agamben in their later works. (shrink)

La violencia contra la mujer en la pareja es un fenómeno registrado en las sociedades a lo largo de la historia. Con el f in de averiguar cuáles son las causas que favorecen su aparición se han desarrollado teorías desde diferentes perspectivas —psicológica, socioló- gica y feminista, principalmente— que han tratado que determinar cuáles son los factores que aumentan el riesgo de que exista este tipo de violencia. El propósito de este artículo es exponer los postulados de las principales las (...) teorías criminológicas que han tratado el maltrato en la pareja en el ámbito internacional. Conocer las variables de riesgo de esta problemática social puede servir para diseñar políticas publicas de prevención y erradicación de la violencia contra la mujer en la pareja. (shrink)

En este artículo se propone una lectura del diálogo platónico el Banquete, en la que se destaca que la composición del texto refleja la dinámica del dios Dioniso. La represión, sufrimiento y venganza de la característica actuación del dios, su complejidad y su estrecha relación con lo emocional, se develan a través de los diversos discursos eróticos del diálogo. Tras describir algunos indicios sobre la presencia de Dioniso en la composición de la obra, se expone el caso concreto de Pausanias: (...) su posición en el preámbulo del banquete, el análisis de su discurso erótico en relación y contraste con la figura dionisíaca de Agatón. Desde este punto de vista, eldiscurso viril y sociológico de Pausanias, como tradicionalmente se lo entiende, se muestra considerablemente distinto y revela una dimensión erótica y emocional que suele pasar desapercibida. (shrink)

Este artigo aborda a temática ética na obra Suma Teológica de Tomás de Aquino. Mais precisamente visamos demonstrar a maneira em que se dá o tratamento da moralidade no âmbito social, no interior das comunidades. Tenho a intenção neste trabalho de ajudar a explicitar o caráter comunitário da ética de Tomás de Aquino, e mais precisamente, estou interessada em delimitar criticamente os elementos constitutivos da formulação filosófica por Tomás de Aquino do conceito de comunidade moral na Suma Teológica.

Previous research has demonstrated that people are susceptible to developing false memories, that is to recall events that did not actually occur or recall them differently than they occurred (Dods...

Formas de representación de la violencia en El vuelo del tigre y Libro de navíos y borrascas de Daniel Moyano.